ShcA Adaptor Protein Promotes Nephrin Endocytosis and Is Upregulated in Proteinuric Nephropathies
نویسندگان
چکیده
منابع مشابه
CD36 mediates proximal tubular binding and uptake of albumin and is upregulated in proteinuric nephropathies.
Dysregulation of renal tubular protein handling in proteinuria contributes to the development of chronic kidney disease. We investigated the role of CD36 as a novel candidate mediator of albumin binding and endocytosis in the kidney proximal tubule using both in vitro and in vivo approaches, and in nephrotic patient renal biopsy samples. In CD36-transfected opossum kidney proximal tubular cells...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2017
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.2017030285